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. 1996 Jul 15;16(14):4322–4334. doi: 10.1523/JNEUROSCI.16-14-04322.1996

Fig. 7.

Fig. 7.

Treatment with PTX prevents inhibition of glutamatergic synaptic transmission by Win 55,212-2. A, PTX pretreatment (500 ng/ml, 24–28 hr) prevented 100 nm Win 55,212-2 inhibition of 0.1 mm[Mg2+]o-induced [Ca2+]i spiking.B, Heat-inactivated PTX (15 min, 95°C) pretreatment (500 ng/ml, 24–28 hr) did not affect 100 nm Win 55,212-2 inhibition of low [Mg2+]o-induced [Ca2+]i spiking.C, Histogram summarizing the effects of pretreating cultured hippocampal neurons with PTX, CTX (1 μg/ml, 4 hr), and heat-inactivated PTX on 100 nm Win 55,212-2 inhibition of low [Mg2+]o-induced [Ca2+]i spiking (n = 9 for control and PTX treated, n = 6 for CTX treated and heat-inactivated PTX treated). Error bars represent SEM. Asterisks indicate significantly different from control; p < 0.001 (ANOVA with Bonferroni post-test).