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Significant decreases in neuronal number were present in all layers of EC in the AD brains (n = 10) when compared with the nondemented group (n = 10). Decrease in cell number in the AD group was highest in layer II compared with other layers (layer II, 72%, p < 0.001; layer III, 41%, p < 0.01; layer IV, 55%,p < 0.001; layers V, VI, 40%, p < 0.01).
