Fig. 6.

Histological analysis of the quadriceps muscle of PMP22-transgenic and wild-type mice. Normal chessboard-like distribution pattern of types I (slow-twitch muscle,dark) and II (fast twitch muscle, light) muscle fibers of wild-type animals (A). PMP22-transgenic animals (B, C) show prominent segregation and grouping of types I and II fibers (B) and few hypertrophic fibers (arrows) but no significant atrophy. C, Late stage of neurogenic myopathy with type grouping and large groups of atrophic fibers. Scale bar, 25 μm.