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Ventilatory responses of individual neonatal mice to hyperoxia (A) and hypercapnia (B). Records show periods of quiet breathing without apneas.A, Hyperoxia depresses ventilation in P2.5 wild-type (+/+) mice, primarily via a decrease in VT, but had no significant effect on either VTor f in knockout (−/−) animals. B, P3 knockout mice were capable of increasing respiratory output above resting normoxic levels in response to 5% CO2. Scale bars: vertical, 20 μl; horizontal, 2 sec.
