Fig. 10.

Huntingtin immunoreactivity in neonatal mouse brain. a, By P0, the cerebral cortex exhibits immunoreactivity in all neurons. b, In the upper cortical layers, the somata (arrow) and leading processes of some of the labeled cells show the characteristic morphology of migrating neurons (curved arrows). c, P1 pyramidal neurons become more intensely labeled than other cortical cells. d, Some cells in the P0 pyriform cortex (asterisk) are intensely stained, but the caudate/putamen (cp) is stained more weakly. e, f, In the P7 cortex, the labeling of layer V pyramidal neurons is striking (boxed area is enlarged inf). At this age, some layer VI neurons are also intensely labeled (arrow in e). g, P0 pyriform cortex. Note the increased staining in pyramidal somata and emerging processes (curved arrows). Scale bars:a, 100 μm, and also applies to d ande; b, 50 μm, and also applies to c,f, g.