Fig. 8.

Huntingtin immunoreactivity in axon trunks and terminals in the adult mouse brain. Axon trunks are labeled in the internal capsule (a) and the cerebellar peduncle (b). Individual axons can be distinguished in the cerebellar peduncle (arrows in b). Immunoreactive puncta interpreted to be axon terminals appear in the thalamus when minimally fixed frozen sections are pretreated with methanol (see Materials and Methods). c, Neuronal cell bodies are also labeled. Scale bars: a, 50 μm, and applies to b; c, 50 μm.