Fig. 9.

Huntingtin immunoreactivity in embryonic and early postnatal mouse brain. a, By E15, the perikarya of some basal forebrain neurons acquire intense immunoreactivity (arrows in a). Note that cells of comparable or smaller size located near the intensely labeled cells are still weakly immunoreactive. b, Clusters of brainstem neurons show increased labeling in E17 mouse brain. c, Enlargement of framed area in b. Note the intense staining of the cytoplasm (arrows) but the absence of labeling in processes.d, By P1, huntingtin-positive neurons contribute to the segregated clusters of brainstem nuclei. e, Brainstem neurons at higher magnification show robust labeling in perikarya and emerging processes (curved arrows). Scale bars:a, 50 μm, and applies to c and e;b, 100 μm; d, 200 μm.