Table 1.
Effect of paired-pulse and tetanic stimulation on mEPSC peak amplitude
mEPSC peak amplitude (pA) | ||||
---|---|---|---|---|
Cell number | Before stimulation | After stimulation | Significance | |
Paired pulse | 1 | 17.6 ± 6.9 | 18.0 ± 6.7 | NS |
2 | 21.2 ± 12.5 | 17.9 ± 6.1 | NS | |
3 | 54.1 ± 41.9 | 49.9 ± 27.7 | NS | |
4 | 42.8 ± 22.0 | 36.8 ± 20.1 | NS | |
5 | 20.2 ± 8.6 | 20.2 ± 5.6 | NS | |
6 | 22.9 ± 8.8 | 22.6 ± 8.8 | NS | |
Tetanic | 1 | 21.1 ± 9.8 | 23.6 ± 10.8 | p < 0.05* |
2 | 18.2 ± 8.6 | 17.3 ± 7.6 | NS | |
3 | 42.0 ± 22.8 | 41.0 ± 14.4 | NS | |
4 | 26.6 ± 17.6 | 27.7 ± 11.7 | NS | |
5 | 15.1 ± 8.3 | 14.9 ± 8.5 | NS | |
6 | 29.5 ± 16.2 | 31.4 ± 19.0 | NS |
*Note mEPSCs are slightly larger after stimulation, despite depression of evoked responses.
NS, Not significant; paired-pulse stimulation at 1 sec ISI.
Tetanic stimulation pattern = 10 action potentials at 20 Hz.