Fig. 10.

LTP reversal in aged slices is inhibited by AP5.A, Plot of EPSP slopes for an individual aged slice. LTP (HFS) was established, and AP5 was then introduced to the recording medium. No LTP reversal was observed when LFS was delivered in the presence of AP5 (LFS1). In drug-free media, however, a second episode of LFS (LFS2) resulted in substantial depression. B, Statistical summary for six aged slices in which LTP reversal was attempted in the presence of AP5. Asterisk indicates a difference between LFS2 and LFS1; p < 0.05. Bars represent SEM.