Fig. 3.

Effect of systemic preadministration of ZK 93,426 or its vehicle on the darkness/cereal-induced increase in cortical ACh efflux (mean ± SEM) in 192 IgG-saporin-lesioned animals (n = 7). The darkness/cereal stimulus, presented 15 min after systemic injection of vehicle solution, increased efflux by 91 ± 32% over baseline efflux during the first collection interval. This effect was potentiated by systemic administration of ZK 93,426 at the 1.0 mg/kg dose (peak = 156 ± 47%) but not the 5.0 mg/kg dose (peak = 94 ± 31%). last bsln, Last baseline.