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Representative coronal brain sections (stained for AChE-positive fibers) from a sham-lesioned animal (A) and a 192 IgG-saporin-lesioned animal (B). Cortical infusions of 192 IgG-saporin resulted in a 40–60% reduction of AChE-positive fiber density in the medial and dorsal parietal areas. The arrow in B marks the transition from an extensively depleted dorsal cortical area (near the toxin infusion site) to a less depleted more ventral zone. Magnification, 10×.
