Fig. 6.

Comparison of GIRK1, GIRK2, and IRK1 staining between wild-type and wv mouse cerebellum. Parasagittal views of cerebella from wild-type mice and from PND19 wvmice (inset) counterstained with toluidine blue (A) or stained with antibodies against GIRK2 (B), GIRK1 (C), and IRK1 (D). There is a dramatic loss of the granule cell layer (g) and corresponding reduction in the staining of GIRK2 and GIRK1. The IRK1 staining of Purkinje cell body (p) and dendrites still persists in thewv cerebellum. The magnification is the same in each panel and in the insets. m, Molecular layer. Scale bar, 0.2 mm.