Table 1.
Quantitative kinetic data for onset of inactivation in Na+ channel chimeras
| Channel | +/− hβ1 | τf(msec) | p1_a | τs(msec) | p | Fast fraction | p | (n) |
|---|---|---|---|---|---|---|---|---|
| hSkM1 | − | 2.2 ± 0.3 | 13.2 ± 1.4 | 0.30 ± 0.03 | (20) | |||
| hSkM1 | + | 1.1 ± 0.1 | 1_150 | 8.4 ± 0.8 | 1_150 | 0.84 ± 0.01 | 1_150 | (28) |
| hSkM1–P14 | − | 1.0 ± 0.3 | 8.1 ± 0.8 | 0.20 ± 0.04 | (9) | |||
| hSkM1–P14 | + | 1.1 ± 0.1 | NS | 9.0 ± 0.8 | NS | 0.28 ± 0.04 | NS | (10) |
| hH1 | − | 1.2 ± 0.1 | 5.8 ± 0.6 | 0.78 ± 0.03 | (11) | |||
| hH1 | + | 1.0 ± 0.1 | NS | 5.8 ± 0.6 | NS | 0.75 ± 0.02 | NS | (11) |
| hH1–P1 | − | 1.3 ± 0.2 | 5.5 ± 0.1 | 0.43 ± 0.02 | (10) | |||
| hH1–P1 | + | 1.1 ± 0.1 | NS | 5.7 ± 0.1 | NS | 0.59 ± 0.04 | 1_150 | (10) |
| hH1–P4 | − | 1.3 ± 0.1 | 5.5 ± 0.1 | 0.74 ± 0.01 | (4) | |||
| hH1–P4 | + | 1.3 ± 0.1 | NS | 7.0 ± 0.7 | NS | 0.90 ± 0.02 | 1_150 | (4) |
| hH1–P14 | − | 1.4 ± 0.1 | 6.4 ± 0.3 | 0.57 ± 0.02 | (9) | |||
| hH1–P14 | + | 0.9 ± 0.1 | 1_150 | 4.4 ± 0.6 | 1_150 | 0.80 ± 0.04 | 1_150 | (12) |
| hH1–P14N | − | 1.6 ± 0.1 | 8.3 ± 0.4 | 0.49 ± 0.03 | (16) | |||
| hH1–P14N | + | 1.3 ± 0.1 | 1_150 | 7.3 ± 0.4 | NS | 0.71 ± 0.01 | 1_150 | (8) |
| hH1–P14C | − | 1.2 ± 0.1 | 7.3 ± 0.9 | 0.54 ± 0.03 | (10) | |||
| hH1–P14C | + | 0.9 ± 0.1 | 1_150 | 4.9 ± 0.3 | 1_150 | 0.81 ± 0.03 | 1_150 | (14) |
F1_a
Significance level for comparisons between expression with (+) and without (−) hβ1. NS, Not significant;
F1_150: p < 0.05; τf, time constant for fast component of Na+ channel onset of inactivation; τs, time constant for slow component of Na+channel onset of inactivation.