Table 2.
Quantitative evaluation of D2-like DA receptors in subregions of the striatum and in the olfactory tubercles
| D2-like [3H]-YM-09151-2 | D4-like [3H]-YM-09151-2 + raclopride | |||||
|---|---|---|---|---|---|---|
| Sham (n = 4) | Lesion (n = 5) | % change | Sham (n = 4) | Lesion (n = 5) | % change | |
| PD 39 | ||||||
| CP-dorsolateral | 190 ± 3.6 | 192 ± 4.0 | 1.0 | 76 ± 2.0 | 73 ± 2.8 | −3.2 |
| CP-dorsomedial | 152 ± 2.9 | 140 ± 4.01 | −2.5 | 59 ± 2.9 | 58 ± 2.5 | −2.9 |
| CP-ventral | 138 ± 3.9 | 140 ± 6.67 | 1.7 | 58 ± 2.2 | 57 ± 2.5 | −2.3 |
| Fundus-CP | 120 ± 3.4 | 126 ± 4.2 | −3.0 | 55 ± 2.0 | 52 ± 1.8 | −6.8 |
| Accumbens-core | 92 ± 3.2 | 89 ± 3.9 | −2.7 | 41 ± 1.7 | 38 ± 0.8 | −6.7 |
| Accumbens-shell | 91 ± 3.4 | 84 ± 3.92 | −8.2 | 40 ± 2.0 | 36 ± 0.7 | −9.3 |
| Olfactory tubercle | 85 ± 6.2 | 85 ± 4.5 | −0.3 | 42 ± 1.6 | 48 ± 3.3 | 11.4 |
| PD 60 | ||||||
| CP-dorsolateral | 173 ± 1.7† | 187 ± 6.7 | 8.0 | 73 ± 1.3 | 67 ± 2.1 | −9.3 |
| CP-dorsomedial | 132 ± 4.0 | 140 ± 2.7 | 6.5 | 56 ± 1.2 | 53 ± 1.8 | −6.3 |
| CP-ventral | 125 ± 2.0 | 138 ± 1.8 | 10.0 | 55 ± 1.0 | 54 ± 3.2 | −2.5 |
| Fundus-CP | 107 ± 3.4 | 117 ± 7.3 | 9.8 | 50 ± 1.2 | 52 ± 4.2 | 4.0 |
| Accumbens-core | 84 ± 3.0 | 94 ± 1.9 | 11.5 | 41 ± 2.7 | 39 ± 2.6 | −5.4 |
| Accumbens-shell | 85 ± 3.7 | 101 ± 3.42_150† | 18.7 | 42 ± 4.2 | 44 ± 4.8 | 2.9 |
| Olfactory tubercle | 89 ± 4.3 | 92 ± 3.5 | 3.5 | 49 ± 1.9 | 53 ± 1.3 | 8.9 |
Receptor levels are expressed in fmol/mg wet tissue and represent the mean ± SEM of pooled values obtained from four sections per animal. Striatal subregions are defined according to Paxinos and Watson atlas (1986). CP, Caudate-putamen.
F2_150: p < 0.05 compared with age-matched sham group;
F2_152: p < 0.05 compared with corresponding PD39 group.