Table 3.

Quantitative evaluation of D2–D3 DA receptors by autoradiography and D2 mRNA by in situ hybridization in subregions of the striatum and in the olfactory tubercles

	D2 + D3 [3H]-YM-09151-2 − ([3H]-YM-09151-2 + raclopride)			D2 in situ hybridization
	Sham (n = 4)	Lesion (n = 5)	% change	Sham (n = 4)	Lesion (n = 5)	% change
PD 39
CP-dorsolateral	114  ± 5.6	119  ± 3.1	3.8	1.47  ± 0.27	1.63  ± 0.27	11.2
CP-dorsomedial	92  ± 2.1	83  ± 4	−10.4	1.17  ± .2	1.32  ± 0.2	13.1
CP-ventral	80  ± 5.8	83  ± 5.5	4.7	1.21  ± 0.22	1.36  ± 0.2	12.4
Fundus-CP	65  ± 4.9	74  ± 5.0	14.5	1.24  ± 0.22	1.39  ± 0.21	12.7
Accumbens-core	51  ± 4.1	52  ± 2.8	0.5	0.90  ± 0.12	0.92  ± 0.13	2.8
Accumbens-shell	51  ± 4.6	47  ± 3.2	−7.4	0.78  ± 0.1	0.75  ± 0.1	−3.1
Olfactory tubercle	43  ± 5.6	38  ± 3.2	−8.8	2.08  ± 0.22	2.5  ± 0.3	20.1
PD 60
CP-dorsolateral	99  ± 1.5†	120  ± 5.43_151	21.0	2.24  ± 0.08	2.74  ± 0.11††	22.2
CP-dorsomedial	75  ± 4.1	87  ± 2.78	16.3	1.71  ± 0.06	2.19  ± 0.093_150†	27.8
CP-ventral	69  ± 2.2	83  ± 2.6	20.1	1.87  ± 0.04	2.28  ± 0.09††	22.3
Fundus-CP	57  ± 2.6	65  ± 4.5	14.9	1.76  ± 0.03	2.4  ± 0.13_150††	35.8
Accumbens-core	43  ± 2.9	55  ± 1.4	27.7	1.4  ± 0.06††	1.57  ± 0.02††	12.3
Accumbens-shell	43  ± 2.3	58  ± 1.63_150	34.9	1.27  ± 0.07††	1.6  ± 0.083_151††	24.3
Olfactory tubercle	40  ± 3.5	39  ± 2.5	−2.8	2.94  ± 0.03	2.78  ± 0.12	−5.27

Receptor levels are expressed in fmol/mg wet tissue, and in situ hybridization data are expressed as random optical density and represent the mean ± SEM of pooled values obtained from four sections per animal. Striatal subregions are defined according to Paxinos and Watson atlas (1986). CP, Caudate-putamen.

F3_150: p < 0.05;

F3_151: p < 0.01 compared with age-matched sham group;

F3_152: p < 0.05;

F3_153: p < 0.01 compared with corresponding PD39 group.