Fig. 2.

Morphological evidence for a- poptosis in CA1 neurons after ischemia. A, Normal CA1 pyramidal neurons from nonischemic gerbil. B, Margination of condensed chromatin along the nuclear envelope of CA1 neurons 2 d after ischemia. Some neurons exhibit nuclear shrinkage (inset). Occasionally microglia are seen attached to a neuronal cell body (arrowhead). C, Most CA1 neurons have shrunken nuclei by 3 d after ischemia. Clumping of chromatin and late stages of apoptotic morphology are evident. Numerous microglia are found in the CA1 region. D, End-stage apoptosis is evident by 4 d after ischemia (arrow). Some neurons exhibit morphological features of necrosis (inset).