Table 1.
DQA (n= 8) amd DQB (n= 6) mRNA expression was quantified using relative optical densities (ROD) on Northern autoradiograms
White matter | Gray matter | |||||
---|---|---|---|---|---|---|
Narcoleptic | Control | Narcoleptic | Control | |||
p | p | |||||
DQA/β-actin | 0.52 ± 0.06 | 0.002 | 0.25 ± 0.04 | 0.86 ± 0.19 | 0.036 | 0.39 ± 0.07 |
DQA/β-tubulin | 3.07 ± 0.73 | 0.016 | 0.97 ± 0.23 | 1.51 ± 0.53 | ns | 0.75 ± 0.16 |
DQB/β-actin | 0.20 ± 0.02 | ns | 0.15 ± 0.03 | 0.50 ± 0.05 | ns | 0.63 ± 0.11 |
DQB/β-tubulin | 1.66 ± 0.27 | 0.023 | 0.81 ± 0.16 | 0.79 ± 0.07 | ns | 1.29 ± 0.22 |
ROD values (means ± SEM) were calculated using β-actin and β-tubulin measurements as internal controls. Comparisons are based on post hoc t test comparisons between the narcoleptic and the control group. ns, Not significant.