Fig. 1.

Schematic representation of the experimental design used in this study. The average daily dose of 3NP administered to the four baboons is indicated as a function of time. Dose regimen was adjusted every week according to the physical status of each animal to avoid any acute intoxication (Brouillet et al., 1995). The various behavioral tests used to assess the presence of motor deficits (apomorphine tests, APO1–3) or frontostriatal cognitive dysfunction (ORDT) in the 3NP-treated baboons, are represented as open boxes. Note that APO1 and APO2 were performed immediately before and after the ORDT testing to assess the functional status of the striatum at that particular time period and possibly correlate cognitive deficits with presymptomatic striatal dysfunction.