Fig. 4.

Striatal pathology in 3NP-treated primate.A, MR T2-weighted image obtained after completion of the 3NP in the same animal as in Figure 3. High signal intensity within the caudate nucleus and putamen corresponds to tissue damage seen inC. B and C, Double-stained sections reacted to reveal the presence of calbindin, which labels a subpopulation of medium-size spiny neurons, and NADPH-diaphorase enzyme, which labels somatostatin/neuropeptide Y-interneurons in the caudate nucleus of the 3NP-treated animal (C) in comparison with a normal (control) specimen (B). Note the severe loss in calbindin-positive neurons and the relative sparing of the NADPH-diaphorase neurons (dark neurons with dendritic arbors) in the treated animal as compared with the control. [Same magnification inB and C; scale bar (shown in C): 100 μm.]