Fig. 6.

ORDT performances in 4 3NP-treated baboons and 10 age-matched control animals. The percentage of “SUCCESS” (A), “CORRECT” (B), “BARRIER HITS” (C), and “MOTOR PROBLEMS” (D) responses are represented asblack bars for control animals (n = 10) andcross-hatched bars for the 3NP-treated animals (n = 4). Values are mean ± SEM. Statistical analysis was carried out using ANOVA repeated-measures and then reanalyzed post hoc using Scheffe’s F test to determine significant interactions between groups (3NP-treated vs control subjects). Success and correct responses are expressed as a percentage of the total number of trials. Correct responses include success responses. Barrier hits and motor problems are expressed as a percentage of the total responses registered. As compared with controls, 3NP animals seemed significantly impaired in their ability to reach the reward in the first attempt (success responses), which resulted in a higher number of barrier hits that reflect a lack of inhibition of their natural prepotent tendency and a dysfunction of the frontostriatal pathway.