Table 3.

Brain areas showing inflammation after a footpad injection of AdRL

	Days after footpad injection
	14					21							28
	A	B	C	D3_a	E3_a	A	B	C	D	E3_a	F3_a	G3_a	A	B	C	D
Frontal cerebral cortex
Ipsilateral	.	.	.	.	.	+	+	+	+	+	+	+	+	+	+	+
Contralateral	.	.	.	.	.	.	+	+	.	+	+	+	+	+	+	+
Caudate (injection site)	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+
Globus pallidus, ipsilateral	.	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+
Amygdala, ipsilateral	.	.	.	.	.	.	.	.	.	.	.	+	.	.	+	.
Thalamus, ipsilateral	.	.	.	.	.	+	+	+	+	+	+	+	+	+	+	+
Substantia nigra/ventral tegmental nucleus
Ipsilateral	.	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+
Contralateral	.	.	.	.	.	.	.	.	.	+	.	+	.	.	+	.
Dorsal raphe	.	.	.	.	.	.	.	.	.	.	+	.	+	.	+	.
Locus coeruleus
Ipsilateral	.	.	.	.	.	+	+	.	.	+	+	+	+	+	+	+
Contralateral	.	.	.	.	.	+	.	.	.	.	.	.	.	.	.	+

Two months before a footpad injection of AdRL, rats had received AdRL injections into the right caudate. For each rat, brain areas showing upregulation of MHC I on microglial cells and infiltration of MHC I-positive round cells are marked as positive. Most of these areas also showed perivascular cuffing.

^F3_aThese rats, as part of a separate experiment, received a transection of the right optic nerve on day 7 after the footpad injection of AdRL.