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Effect of cadmium on mIPSCs. Amplitude histograms derived from 4 min stretches (bin width, 2.0 pA) in control (A, 267 events), in the presence of 100 μmcadmium (B, 138 events), and after 10 μmdopamine (C, 94 events) in the continuing presence of cadmium. Arrows indicate the mean amplitudes of mIPSCs in control, in cadmium, and in dopamine/cadmium (21.5, 20.7, and 20.5 pA, respectively). mIPSCs were recorded in 7.5 mmCaCl2, 0.5 μm TTX, and 5 μmCNQX at a holding potential of −70 mV.
