Fig. 1.

One afterdischarge increases BDNF and c-fos mRNAs in the presence of anisomycin. Dark-field photomicrographs showing the autoradiographic localization of pan-BDNF cRNA (A–C) and c-fos cRNA (D–F) in situhybridization in sections through hippocampus and cortex of a control rat (A, D) and experimental rats treated with a PD alone (B, E) or with a PD in the presence of anisomycin (C, F). For BDNF cRNA, the density of labeling in stratum granulosum (sg) appears similarly increased in the PD (B) and PD–anisomycin (C) rats in comparison with the paired control (A). For c-fos cRNA, the PD alone (E) clearly increased labeling in both neocortex and neuronal lamina of hippocampus, whereas the PD + anisomycin (F) increased hybridization in these areas as well as in the hippocampal molecular layers (placement indicated by asterisk inD). Scale bar, 1 mm.