Fig. 5.

Spontaneous IPSCs mediated by GABA are reduced in frequency by baclofen but enhanced by serotonin. A, Spontaneous transient outward currents were abolished by TTX (1 μm) and also (B) by picrotoxin (50 μm). C, Spontaneous IPSCs were increased in frequency by serotonin (10 μm), which was reversible on washout. D, Spontaneous IPSCs were abolished reversibly by baclofen (3 μm). Records are from four different cells voltage-clamped at −50 mV, with CNQX (10 μm) and d-AP5 (50 μm) present throughout in all cases.