Skip to main content
. Author manuscript; available in PMC: 2019 Jun 17.
Published in final edited form as: Nat Struct Mol Biol. 2018 Oct 29;25(11):1047–1058. doi: 10.1038/s41594-018-0142-5

Figure 1: SLFN11 selectively inhibits ATR/ATM protein expression and sensitizes cells to death upon DNA damaging agents treatment.

Figure 1:

a, Relative viability of FG cells expressing control or SLFN11 shRNA was measured by MTS assay after 48 hours of CPT or DMSO treatment (biological replicates, mean ± s.d., n = 3). b, Immunoblot analysis of ATR and ATM protein levels after 40 nM CPT or DMSO treatment in FG cells expressing control or SLFN11 shRNA. c, Relative ATR and ATM mRNA levels as determined by qPCR in FG cells expressing control or SLFN11 shRNA after 40 nM CPT or DMSO treatment (mean ± s.d., n = 3). d, e, f, As in a, b, c, except with HEK293 cells. g, h, i, As in d, with additional DDAs as specified. j, Microscopic images of HEK293 cell cultures after 24 hours of CPT. Uncropped images are shown in Supplementary Data Set 1.