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. 1996 May 15;16(10):3189–3198. doi: 10.1523/JNEUROSCI.16-10-03189.1996

Fig. 6.

Fig. 6.

A second inhibitor of PKA, KT-5720, also prevents full expression of L-LTP in the MPP. A1, A 30 min application of 1 μm KT-5720, beginning 15 min before tetanization, elicited a delayed decline of potentiation beginning 30–40 min after tetanization. Levels of facilitation in drug-treated slices were significantly lower than those in control slices beginning 60 min after tetanization (p < 0.05 for 60 min after tetanization and all times thereafter). L-LTP was induced using the same protocol as in Figure 5. Sample field EPSP sweeps were recorded 10 min before and 3 hr after the start of tetanization. Calibration bars: 2 mV, 4 msec. A2, Short-lasting facilitation induced by three 100 Hz trains (delivered once/min at twice test pulse width) is unaffected by 1 μm KT-5720. The inhibitor was applied for the same time window as in part A1 of this graph. Controls,Filled symbols. B, Acute exposure of slices to 1 μm KT-5720 for 30 min had no effect on baseline field EPSPs evoked by 0.02 Hz stimulation of the MPP. KT-5720 was dissolved in DMSO (0.1% final concentration).