Fig. 6.

Effects of binocular deprivation on visual cortical responses in the mouse. A, RF sizes in BD and normal mice. The mean ± SD is shown for RFs of neurons recorded in each animal (mo105 to mo326). The overall mean ± SEM are shown for all four BD animals (All BD) and all five ND animals (All ND); n = 15–54 cells per animal, n = 137 and 124 cells for All BD and All ND, respectively. B, Retinotopy in BD and normal animals. Series of three to five evenly spaced penetrations were made across a portion of the lateromedial extent of V1 in BD and ND animals. The RF centers of three to five neurons encountered at each location are plotted here for one representative series of penetrations from a BD (circles) and an ND animal (triangles).Solid and dotted lines show linear regressions of RF center azimuth on electrode position in the BD and normal animal, respectively. Inset shows mean ± SD correlation coefficients of two and four regressions each from BD and normal animals, respectively. C, OD distribution of 132 neurons recorded from the binocular zone in the BD mice. Conventions as in Figure 2. The OD distribution for ND animals is shown in Figure8A. D, Visual evoked responses in single neurons recorded from the binocular zone in ND, BD, andMD mice. Mean ± SEM of responses of neurons to computer-generated stimuli presented to both eyes (gray bars), the ipsilateral eye (white bars), or the contralateral eye (hatched bars) are shown. Responses are calculated separately for neurons recorded contralateral (contra MD) and ipsilateral (ipsi MD) to the deprived eye. For each neuron, the response to eight presentations (four in each direction) of a bar of each orientation were averaged; n = 11–24 cells for each category. Both MD and BD mice were deprived from P28 to P32.