Table 1.

Gross brain measurements (mm)

	Euploid	Ts16	% Difference
E14
R–C	3.15  ± 0.08	2.83  ± 0.12*	11.2
P–P	3.28  ± 0.05	2.85  ± 0.15*	14.1
E16
R–C	4.20  ± 0.13	3.63  ± 0.24**	14.6
P–P	4.63  ± 0.14	4.12  ± 0.08*	11.0
E18
R–C	5.13  ± 0.15	4.22  ± 0.10**	18.7
P–P	5.68  ± 0.12	5.24  ± 0.20**	8.7

Mean values ± SEM for telencephalic dimensions in the rostral–caudal (R–C) and parietal–parietal (P–P) axes of euploid and Ts16 mice at E14, E16, and E18 (n = 4 pairs for all ages). *p < 0.05; **p < 0.005.