Table 3.

Neurotrophin effects on survival of total and AChE-positive neurons after 24 hr hypoglycemic stress

Treatment	Total neurons/stress control	AChE+ neurons/stress control
NGF	6.62  ± 1.07  (43)*	1.78  ± 0.34  (128)
BDNF	2.94  ± 0.68  (26)*	1.98  ± 0.43  (52)
NT-3	3.13  ± 0.68  (26)*	2.60  ± 0.74  (65)*
NT-4	2.33  ± 0.37  (27)*	1.45  ± 0.47  (44)
No stress	9.43  ± 1.41  (44)*	1.80  ± 0.30  (48)

Total neuronal survival was measured after exposure to zero glucose, AChE-positive neuronal survival after exposure to 55 μm glucose. Other protocols are as for Figure 6. Values are normalized to those measured in sister cultures stressed in the absence of exogenous neurotrophin, which were 7.8 ± 1.22 total neurons/mm² (24 wells in 4 experiments) and 5.15 ± 0.61 AChE-positive neurons/mm² (119 wells in 5 experiments). Number of culture wells for each treatment is indicated in parentheses. *, Significant difference from stress control at p ≤ 0.05.