Fig. 5.

Rotational behavior after 6-OHDA lesioning is altered by the KA-bridged transplant in the amphetamine-challenge (5 mg/kg, i.p.) paradigm. Ipsilateral turnings are evident after 6-OHDA lesioning (a). After the KA-bridged transplantations, three types of turning behaviors are observed: (1) a reduction in ipsilateral rotational turning (b), (2) a mixture of low ipsilateral and contralateral turning (c), and (3) an appearance of contralateral rotational turning (d). The incidence of amphetamine-induced ipsilateral turns is significantly reduced (p < 0.0005, pairedt test, n = 8) or reverted to contralateral turning (4 of 8) after bridged transplant (e).