Fig. 7.
Comparison of effects between salicylate and lanthanide on OHC capacitance and movement. Voltage-dependent capacitance and voltage-induced length change were measured before and during extracellularly applied LuCl3 (1 mm) in an OHC with intracellularly applied salicylate (10 mm). Length changes were induced by 20 mV steps from −20 to +60 mV at aVhold of −80 mV.Rs, 4.75 MΩ andRm, 89.2 MΩ (closedcircles); Rs, 4.39 MΩ andRm, 261 MΩ (opencircles). Fits (solid lines) for capacitance indicate VpkCm,Qmax, and z of −42.3 mV, 9.152 pC, and 0.205 (open circles); −71.3 mV, 7.35 pC, and 0.191 (closed circles). Fitting such depressed capacitance functions may not be reliable because of the limited voltage range that can be applied. The mechanical data could not be fit reliably with a two-state Boltzmann. Note that lanthanides, although changing the capacitance function minimally, effectively block mechanical responses. The inset shows mechanical gain of the cell under each condition.