Fig. 8.

Effects of acute perfusion of calcium channel blockers on control serum- and Patient II serum-treated motoneurons. Calcium currents were evoked at +10 mV in control serum-treated motoneurons (A) or Patient II serum-treated motoneurons (B) 1 min before and 5 min after acute perfusion with 10 μm nimodipine (left) or 5 μm ω-CTx MVIIC (right).C, Normalized peak calcium current at +10 mV is plotted with respect to time for motoneurons treated with control serum (left) or serum from Patient II (right) and exposed to either nimodipine (squares) or ω-CTx MVIIC (triangles). The circles plot peak current as a function of time in control serum-treated motoneurons not exposed to either antagonist (n = 7).