Fig. 4.
The distribution of conductance states expressed by −/− mice is very similar to that observed in young rats.A, The proportional distribution of measured conductance levels in mature (>P14) wild-type mouse granule cells. B, The proportional distribution of measured conductance levels in mature (>P14) homozygous mutant (−/−) mouse granule cells (filled columns) and those measured in young (<P12) rat granule cells. All three groups show similar distributions of conductances of >39 pS. There is a marked difference in the distribution of conductances of <39 pS. The −/− mice appear to more closely resemble the young wild types and completely lack the low-conductance NMDA receptor channel.