Fig. 5.

Whole-cell recordings of spontaneous NMDA receptor channel activity in mature NR2C −/− granule cells are made up exclusively of large conductance events. A, A representative recording from a P16 −/− mouse granule cell at −60 mV. The open time (B, dwell time) and amplitude–frequency (C) distributions were fit by single-component functions (m = 43 pS; τ = 2.9 msec). D, The single-channel currents displayed linear I–Vrelations and reversed near 0 mV.