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NMDA receptor channels in excised outside-out patches from mature NR2C −/− granule cells lack low-conductance events. A, Single-channel currents activated by NMDA (20 μm) applied to a patch excised from a P15 NR2C −/− granule cell. Like the spontaneous channel openings observed in whole-cell recordings (Fig. 5), the NMDA-activated single-channel currents are made up exclusively of channels of large conductance (B) and long mean open time (C).
