Fig. 8.

Mossy fiber-evoked macroscopic EPSCs in wild-type (+/+) and NR2C −/− granule cells. A, B, The composite mossy fiber-evoked EPSCs of granule cells in wild-type (+/+) and NR2C-deficient (−/−) mice recorded under control conditions (Control) and in the presence of CNQX (10 μm) and glycine (10 μm) to pharmacologically isolate the NMDA receptor-mediated component.C, The NMDA receptor-mediated components from the cells illustrated in A and B are superimposed, with the relative amplitudes vertically scaled to the mean observed in all cells (Table 1A) to illustrate the similarity of the net charge in the two cell types. D, The NMDA receptor-mediated currents from the cells illustrated in A and B are superimposed with their amplitudes scaled to the same peak, to illustrate the faster rate of decay of the synaptic current in granule cells from NR2C −/− mice.