Table 1.
Excitatory synaptic currents in mouse cerebellar granule cells
| Cell type | Rise time (msec) 10–90% | Amplitude* (pS/pF) | Qtotal (pC) | Decay time (msec)* 10–90% | Decay rate (msec) | ||
|---|---|---|---|---|---|---|---|
| τfast* | τslow | F/Sb | |||||
| A. Properties of pharmacologically isolated NMDA receptor-mediated EPSCs1_a | |||||||
| +/+ | 5.5 ± 0.8 | 135.3 ± 15.1 | 4.3 ± 1.1 | 211.6 ± 22 | 42.3 ± 6.0 | 150.6 ± 8.8 | 1.5 ± 0.5 |
| −/− | 5.0 ± 0.4 | 278.5 ± 42.1 | 4.2 ± 0.9 | 114.3 ± 22 | 23.0 ± 2.9 | 184.0 ± 43.5 | 3.9 ± 1.0 |
| Cell type | Rise time (msec) 10–90% | Amplitude* (pS/pF) | Qtotal (pC) | Decay time (msec)* 10–90% | Decay rate (msec) | ||
|---|---|---|---|---|---|---|---|
| τfast* | τslow | F/Sb | |||||
| B. Properties of mossy fiber-evoked synaptic currents | |||||||
| +/+ | 0.46 ± 0.04 | 434.6 ± 65.0 | 8.0 ± 1.8 | 270.6 ± 49.5 | 44.3 ± 6.5 | 199.6 ± 24.2 | 1.5 ± 0.4 |
| −/− | 0.50 ± 0.02 | 205.2 ± 56.6 | 6.4 ± 1.2 | 165.6 ± 23.3 | 32.4 ± 3.5 | 303.0 ± 51.0 | 4.9 ± 1.2 |
All data are given as mean ± SE. Data are derived from measurements of 17–51 granule cells in each group.
F1_a
NMDA receptor-mediated synaptic currents were recorded in the presence of CNQX (10 μm) and glycine (10 μm).
F1_b
F/S represents the ratio of the amplitudes of the fast (F) and slow (S) exponential components of decay of the EPSC.
*Denotes statistically significant difference (p < 0.05, Student’s ttest).