Table 2.
Differential Plasma Lipids and Proteins Between the Control and PEs Groups
| Compound | Control Group | PEs Group | p | FDR | LR |
|---|---|---|---|---|---|
| Lipid | |||||
| PC(34:1) | 2571.91 | 3013.09 | .0002 | .0066 | 1 |
| PC(34:2)a | 3759.47 | 4303.88 | .0002 | .0066 | 2 |
| PC(32:1) | 238.88 | 319.25 | .0011 | .0161 | 3 |
| PC(36:4)a | 135.46 | 160.55 | .0023 | .0241 | 4 |
| PC(36:2) | 2940.24 | 3421.47 | .0003 | .0067 | 5 |
| LPC(16:1) | 38.27 | 41.69 | .0080 | .0361 | 6 |
| LPC(18:1)a | 231.84 | 273.67 | .0029 | .0259 | 7 |
| LPC(20:3)a | 37.21 | 41.58 | .0050 | .0259 | 8 |
| PC(36:1) | 721.67 | 945.44 | .0008 | .0137 | 10 |
| LPC(18:2)a | 394.75 | 486.68 | .0045 | .0259 | 11 |
| PC(38:2) | 70.50 | 86.11 | .0023 | .0241 | 12 |
| PC(O-38:6) | 28.13 | 33.58 | .0037 | .0259 | 14 |
| PC(38:3) | 616.10 | 752.18 | .0079 | .0361 | 15 |
| PC(30:0) | 56.88 | 73.01 | .0098 | .0414 | 16 |
| PC(32:0) | 175.51 | 204.39 | .0041 | .0259 | 17 |
| PC(36:3) | 1753.26 | 2059.53 | .0049 | .0259 | 23 |
| Protein | |||||
| PLGb | 843,597,014.93 | 1,052,478,260.87 | .0006 | .0138 | – |
| F11 | 16,925,970.15 | 19,053,478.26 | .0304 | .2379 | – |
| SERPINF2 | 487,134,328.36 | 542,565,217.39 | .0324 | .2379 | – |
The p value of the Mann-Whitney U test and loading rank of double cross-validation partial least squares discriminant analysis are shown.
F11, coagulation factor XI; FDR, false discovery rate; LPC, lysophosphatidylcholine; LR, loading rank; PC, phosphatidylcholine; PD, psychotic disorder; PEs, psychotic experiences; PLG, plasminogen; SERPINF2, alpha2-antiplasmin.
a
Increased compounds in agreement with O’Gorman et al. (22) including PD individuals.
b
Increased compounds in agreement with English et al. (23) including PD individuals.