Table 2.

Structures of HIV TAR in complex with peptides or proteins

TAR RNA	Ligand source	Ligand scaffold	Method	PDB codes	Refs.
BIV	BIV Tat (68–81)	Peptide	NMR	1mnb	73
BIV	BIV Tat (65–81)	Peptide	NMR	1biv	75
BIV	BIV Tat-derived peptide	Cyclic peptide	NMR	2a9x	82
BIV	JDV Tat ARM	Peptide	NMR	1zbn	155
EIAV	EIAV CycT1-Tat	Protein complex	X-ray	2w2h	135
HIV-1	Designed Tat mimic L-22	Cyclic peptide	NMR	2kdq	70
HIV-2	Lead compound	Arginine-pyrimidine tripeptide	NMR	2kmj	32
HIV-1	Designed Tat mimic KPZ-41	Cyclic peptide	NMR	2kx5	62
HIV-1	L-22 (low population)	Cyclic peptide	NMR	5j2w	67
HIV-1	HIV-1 Tat (1–49)-SEC	Protein complex	X-ray	5l1z	68
HIV-1	HIV-1 Tat (1–49)-SEC	Protein complex	X-ray	6cyt	139
HIV-1	TBP6.7	Lab-evolved protein	X-ray	6cmn	77
HIV-2	HIV-1 Tat (44–60)	Peptide	NMR	6mce	76
HIV-1	Designed Tat mimic JB181	Cyclic peptide	NMR	6d2u	63