Figure 1.

Cancer-associated EGFR mutations. The y axis shows the number of EGFR mutations reported in different cancer types in the COSMIC database (version 86) (http://cancer.sanger.ac.uk/cosmic).⁸ Please note that the y axis is shown in log₁₀ scale. The total number of EGFR mutations in the database was 21,339. The x axis shows the position of the mutated residue in the EGFR primary sequence. Mutation hot spots, such as L858R and exon 19 deletions, are indicated with labels.