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. 2019 Apr 5;294(24):9377–9389. doi: 10.1074/jbc.RA118.006336

Figure 6.

Figure 6.

Effect of EGFR A702V on kinase interface. Modeled A702V (receiver kinase) interaction with Ile-941 (activator kinase) at the asymmetric dimer interface in the 2.6 Å resolution EGFR X-ray structure with bound ATP peptide analogue (PDB code 2GS6). A structural water (small red sphere) is nearby. Carbon atoms for the Ile-941 and A702V are shown as orange and magenta spheres, respectively; the red and blue spheres, where seen, correspond to main-chain carbonyl oxygen and amino groups, respectively.