Table 1. Details of the FG-Nup stoichiometry for the 24 constructed models to represent the aged NPC. 0 and 1 represent absence and presence, respectively, of the FG-Nup in 8-fold symmetry.

	NSP1	NSP1	NSP1	NSP1	Nup1	Nup42	Nup49	Nup49	Nup57	Nup57	Nup60	Nup100	Nup145	Nup145	Nup159	Nup116
Model 1	0	0	1	1	1	1	1	1	1	1	1	1	1	1	1	0
Model 2	0	0	1	1	1	1	1	1	1	1	1	0	1	1	1	0
Model 3	0	0	1	1	1	1	1	1	1	1	0	1	1	1	1	0
Model 4	0	0	1	1	1	1	1	1	1	1	0	0	1	1	1	0
Model 5	0	0	1	1	0	1	1	1	1	1	1	1	1	1	1	0
Model 6	0	0	1	1	0	1	1	1	1	1	1	0	1	1	1	0
Model 7	0	0	1	1	0	1	1	1	1	1	0	1	1	1	1	0
Model 8	0	0	1	1	0	1	1	1	1	1	0	0	1	1	1	0
Model 9	0	0	1	0	1	1	0	1	0	1	1	1	1	1	1	0
Model 10	0	0	1	0	1	1	0	1	0	1	1	0	1	1	1	0
Model 11	0	0	1	0	1	1	0	1	0	1	0	1	1	1	1	0
Model 12	0	0	1	0	1	1	0	1	0	1	0	0	1	1	1	0
Model 13	0	0	1	0	0	1	0	1	0	1	1	1	1	1	1	0
Model 14	0	0	1	0	0	1	0	1	0	1	1	0	1	1	1	0
Model 15	0	0	1	0	0	1	0	1	0	1	0	1	1	1	1	0
Model 16	0	0	1	0	0	1	0	1	0	1	0	0	1	1	1	0
Model 17	0	0	0	1	1	1	1	0	1	0	1	1	1	1	1	0
Model 18	0	0	0	1	1	1	1	0	1	0	1	0	1	1	1	0
Model 19	0	0	0	1	1	1	1	0	1	0	0	1	1	1	1	0
Model 20	0	0	0	1	1	1	1	0	1	0	0	0	1	1	1	0
Model 21	0	0	0	1	0	1	1	0	1	0	1	1	1	1	1	0
Model 22	0	0	0	1	0	1	1	0	1	0	1	0	1	1	1	0
Model 23	0	0	0	1	0	1	1	0	1	0	0	1	1	1	1	0
Model 24	0	0	0	1	0	1	1	0	1	0	0	0	1	1	1	0