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. Author manuscript; available in PMC: 2019 Jun 17.
Published in final edited form as: Cell Rep. 2019 Jun 4;27(10):2934–2947.e3. doi: 10.1016/j.celrep.2019.05.022

Figure 1. CNS FGF21 Signaling Mediates Low-Protein-Induced Metabolic Responses in Lean Mice.

Figure 1.

(A–L) Brain-specific Klb knockout mice (KlbCamk2a) and control littermates (Klblox/lox) were fed isocaloric control (Con) or low-protein (LP) diet for 7 weeks. (A–I) Circulating FGF21 levels (A), hepatic Fgf21 mRNA levels (B), Klb mRNA levels in various tissues (C), hepatic Phgdh and Asns mRNA levels (D), average daily food intake (E), body weight gain over the experiment (F), final body weight gain (G), final fat gain (H), and final lean gain (I) are shown. (J–L) Oxygen consumption (J) and energy expenditure (K) on days 6–8 of diet exposure and Ucp1 mRNA levels in iWAT and brown adipose tissue (BAT) (L) are depicted.

Data are represented as means ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. 8 mice/group.