TABLE 4.
Binary logistic regression analysis for association with any type of complication
| Variable* | Univariable Analysis | Multivariable Analysis | ||
|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | |
| Time to surgery | ||||
| <8 weeks | 1 | |||
| 8 to 12 weeks | 0.75 (0.53–1.07) | 0.108 | ||
| >12 to 16 weeks | 1.63 (0.94–2.84) | 0.081 | ||
| Sex | ||||
| Female | 1 | 1 | ||
| Male | 1.53 (1.10–2.13) | 0.013 | 1.52 (1.08–2.15) | 0.017 |
| Treatment initiation | ||||
| 2009–2011 | 1 | |||
| 2012–2013 | 0.70 (0.48–1.02) | 0.061 | 0.765 | |
| 2014–2015 | 0.48 (0.32–0.72) | <0.001 | 0.116 | |
| Tumor location height | ||||
| ≤5 cm | 1 | 1 | ||
| <5 to 10 cm | 0.48 (0.33–0.70) | <0.001 | 0.56 (0.37–0.84) | 0.005 |
| >10 to 15 cm | 0.54 (0.34–0.85) | 0.007 | 0.69 (0.41–1.14) | 0.146 |
| ypT stage | ||||
| 0 | 1 | |||
| 1-2 | 1.32 (0.83–2.11) | 0.245 | 0.288 | |
| 3 | 1.23 (0.78–1.95) | 0.371 | 0.705 | |
| 4 | 3.25 (1.27–8.31) | 0.014 | 0.067 | |
| Surgical approach | ||||
| Minimally invasive | 1 | 1 | ||
| Open | 2.17 (1.56–3.02) | <0.001 | 1.70 (1.18–2.45) | 0.004 |
| Type of resection | ||||
| LAR | 1 | |||
| APR | 2.21 (1.50–3.28) | <0.001 | 0.503 | |
| Neoadjuvant regimen | ||||
| ChemoRT alone | 1 | 1 | ||
| Chemotherapyalone | 0.60 (0.34–1.06) | 0.052 | 0.71 (0.39–1.30) | 0.271 |
| TNT | 0.57 (0.40–0.80) | <0.001 | 0.60 (0.42–0.85) | 0.005 |
OR, odds ratio; CI, confidence interval; LAR, low anterior resection; APR, abdominoperineal resection; chemoRT, chemoradiotherapy; TNT, total neoadjuvant therapy.
*
Other than time to surgery, only variables with significant (P < 0.05) or near-significant (P < 0.1) association with complications in univariate analysis are listed. Ileostomy after LAR is not listed because it was not applicable to the whole cohort.