. Author manuscript; available in PMC: 2019 Jul 1.

Published in final edited form as: J Magn Reson Imaging. 2019 Jan 11;50(1):52–61. doi: 10.1002/jmri.26635

Table 3.

Mean ADC and MPF values in the anatomic structures of the fetal brain for the 2^nd and 3^rd pregnancy trimesters.

Structure	ADC × 10⁻⁶ (mm²/s)		MPF (%)
Structure	2^nd trimester (n = 21)	3^rd trimester (n = 21)	2^nd trimester (n = 21)	3^rd trimester (n = 21)
Medulla	1094 ± 170	938 ± 135	3.34 ± 0.42	4.36 ± 0.49^a
Pons	1134 ± 193	977 ± 177	3.27 ± 0.28	3.94 ± 0.38^ab
Thalamus	1335 ± 162^bc	1042 ± 115^a	2.93 ± 0.29^bc	3.72 ± 0.37^ab
Cerebellum	1305 ± 136^bc	1113 ± 195^abc	2.30 ± 0.33^bcd	3.15 ± 0.51^abcd
Frontal WM	1368 ± 178^bc	1357 ± 149^bcde	2.61 ± 0.18^bcde	2.42 ± 0.25^bcde
Temporal WM	1391 ± 169^bc	1334 ± 148^bcde	2.55 ± 0.12^bcd	2.54 ± 0.21^bcde
Occipital WM	1411 ± 197^bc	1363 ± 166^bcde	2.49 ± 0.21^bcd	2.43 ± 0.21^bcde

ADC: apparent diffusion coefficient; MPF: macromolecular proton fraction; WM: white matter.

Note. –Data are mean ± SD. Mean values were compared between trimesters and structures using repeated-measures ANOVA. P values are for post-hoc pairwise comparisons using the Tukey HSD test.

Significantly different from the 2^nd trimester (P < .005).

Significantly different from the medulla within the same trimester (P < .005).

Significantly different from the pons within the same trimester (P < .005).

Significantly different from the thalamus within the same trimester (P < .005).

Significantly different from the cerebellum within the same trimester (P < .05).