Skip to main content
. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Cell Immunol. 2019 Apr 12;341:103918. doi: 10.1016/j.cellimm.2019.04.006

Figure 3. LA effects are pH- and MCT-1-dependent.

Figure 3.

(A) PMC were cultured as in Figure 1C with either 12.5 mM LA or 12.5 mM sodium lactate for 24 hours, then activated by IgE XL for 16 hours. TNF secretion was measured by ELISA. (B) PMC were pretreated with either an MCT-1/2 inhibitor AR-C155858 (100 nM) or DMSO (vehicle) for 1 hour, treated +/− 12.5 mM for 24 hours, then activated via IgE XL for 16 hours. TNF secretion was measured by ELISA. Results are two experiments conducted in triplicate and expressed as mean ±SEM.*, p<0.05; N.S., not significant.