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Spinal Plasticity after Motor Neuron Death. To preserve ventilatory and airway protective functions of respiratory motor network, the following remodeling strategies can be employed: 1) strengthening/weakening existing excitatory/inhibitory synapses and 2) form new synapses or prune existing synapses. 3) Restoration of neuromodulatory (e.g. 5HT) innervation. Consequently, phrenic nerve output can be at least partially be restored following phrenic motor neuron death.
