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. Author manuscript; available in PMC: 2020 Jun 10.
Published in final edited form as: J Control Release. 2019 Apr 9;303:1–11. doi: 10.1016/j.jconrel.2019.04.010

Figure 1. Physicochemical properties and stability of DNA-NP.

Figure 1.

Transmission electron microscopy images of (A) CPN, (B) BPNL, (C) BPNH freshly made in ultrapure water. Scale bar = 400 nm. and (D) Compaction of plasmids in DNA-NP shown by electrophoresis: I) free DNA, II) CPN, III) BPNL, IV) BPNH. Number of plasmids in each DNA-NP and hydrodynamic diameter of DNA-NP when (E) freshly made in water and (F) when incubated in aCSF for 4 hours. (G) Change in hydrodynamic diameters over 12 hours in aCSF at 37°C measured by DLS. Differences are statistically significant as indicated (***p < 0.001), of CPN compared to BPNL and BPNH.