Table #1.
Characteristics of the patients at baseline
| Characteristic | Restrictive fluid group (n=55) |
Usual care group (n=54) |
|---|---|---|
| Age – yr, median (IQR) | 71 (60–82) | 73.5 (54–81) |
| Male sex – n (%) | 24 (43.6) | 26 (48.2) |
| Weight – kg, median (IQR) | 84.3 (75.4–103.5) | 78.3 (69.9–92.3) |
| BMI – kg/m2, median (IQR) | 30.7 (26.8–35.6) | 28.7 (24.3–33.0) |
| Long term care facility resident – n (%) | 10 (18.2) | 9 (16.7)) |
| Physiologic variables | ||
| APACHE II score – meana | 35.4 ±6.9 | 35.7 ±7.4 |
| SOFA score – median (IQR) | 8 (7–11) | 8.5 (7–12) |
| Mean arterial pressure – mmHg, median (IQR) | 51.7 (46.7–55.7) | 53.5 (46.3–58.7) |
| Serum lactate – mmol/liter, median (IQR) | 2.0 (1.4–3.7) | 3.0 (1.5–5.3) |
| Entry criteria – n (%) | ||
| Refractory hypotension | 52 (93.4) | 47 (87.0) |
| Lactic >4mmol/Lb | 2 (3.6) | 7 (13.0) |
| Time from triage to randomization – hours, median (IQR) | 8.8 (4.3–20.8) | 9.1 (5.5–14.5) |
| Chronic medical condition – n (%) | ||
| Diabetes mellitus | 23 (41.8) | 18 (33.3) |
| Chronic kidney diseasec | 20 (36.4) | 6 (11.1) |
| Baseline dialysis | 7 (12.7) | 1 (1.9) |
| Congestive heart failure | 18 (32.7) | 13 (24.1) |
| Chronic respiratory failure | 12 (21.8) | 15 (27.8) |
| Baseline mechanical ventilation | 2 (3.6) | 2 (3.7) |
| Immune modifying medication | 11 (20.0) | 7 (13.0) |
| Chronic liver disease | 5 (9.1) | 8 (14.8) |
| Lymphoma, leukemia, multiple myeloma | 5 (9.1) | 4 (7.4) |
| Metastatic Cancer | 2 (3.6) | 5 (9.3) |
| Organ transplant | 4 (7.3) | 0 (0) |
| Site of infection – n (%) | ||
| Pulmonary | 13 (23.6) | 17 (31.5) |
| Urinary tract | 15 (27.3) | 14 (25.9) |
| Abdominal | 7 (12.7) | 4 (7.4) |
| Skin/soft tissue | 8 (14.6) | 2 (3.7) |
| Endocarditis | 2 (3.6) | 1 (1.9) |
| Indwelling catheter or device | 1 (1.8) | 1 (1.9) |
| Multiple sites | 6 (10.9) | 7 (13.0) |
| Unknown | 3 (5.5) | 8 (14.8) |
a
± indicates standard deviation
b
One patient has missing data
c
Patient baseline characteristics are equally balanced except for chronic kidney disease
IQR= interquartile range