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. Author manuscript; available in PMC: 2019 Jul 5.
Published in final edited form as: Genet Med. 2018 Dec 7;21(7):1507–1516. doi: 10.1038/s41436-018-0373-1

Figure 1.

Figure 1.

Clinical validity classifications of 24 gene-disease pairs associated with syndromic or isolated hereditary colorectal cancer and/or polyposis susceptibility. Consensus genetic and experimental evidence scores are depicted for each gene:disease relationship wherein a Limited preliminary classification scored 0.1-6 total points, a Moderate preliminary classification had 7-11 total points, a Strong preliminary classification scored 12-18 total points, and a Definitive classification scored 12-18 total points and achieved replication over time (indicated by r/t).

Gene:disease pairs associated with syndromic hereditary colorectal cancer and/or polyposis are indicated by dotted black and grey bars for genetic and experimental evidence, respectively. Gene:disease pairs associated with isolated hereditary colorectal cancer and/or polyposis are indicated by solid black and grey bars for genetic and experimental evidence, respectively.